Preparation and Administration

KINERET preparation and administration

What to consider when prescribing KINERET

Here you’ll find helpful information about dosing, administration, expectations, and other things to note as you start your patient on KINERET.

A grandmother (the patient named Peggy) and grandfather play with their grandkids outside on the grass

Storage and handling

KINERET comes in a 100-mg syringe¹

Syringes are prefilled, graduated glass
Single use
Available in a 7-day pack

How to store KINERET¹

Keep in a refrigerator between 36°F and 46°F (2°C-8°C)

Do not freeze or shake

Keep KINERET in its original carton and away from light

For RA: dosing and administration

How to inject KINERET for adults

This video offers simple, step-by-step instructions on how to store and inject KINERET. Be sure to share this video or the printable treatment guide with your patient.

Because of its short half-life, KINERET must be injected daily. RA patients should receive a 100-mg injection around the same time each day.¹

Setting expectations

KINERET may take a few months to start working. Most RA patients who experience improvement see results within 3 months, though some patients continue to improve up to 6 months after starting treatment. It’s important to encourage your patient to continue their treatment plan to see if KINERET is right for them¹

How to inject a child with KINERET

This video offers simple, step-by-step instructions on how to store KINERET and give a child their daily dose. Be sure to share this video or the printable treatment guide with your patient and their family.

Your patient may experience injection site reactions

Injection site reactions (ISRs) are common side effects of KINERET. Most ISRs are mild, and usually stop about 14 to 28 days after starting treatment. Be sure to share tips on managing ISRs from our printable treatment guide with any patient who has been prescribed KINERET.¹

Download patient resources

Important Safety Information

Important Safety Information

INDICATIONS

KINERET^® (anakinra) is an interleukin-1 receptor antagonist indicated for:

Rheumatoid Arthritis (RA). Reduction in signs and symptoms and slowing the progression of structural damage in moderately to severely active rheumatoid arthritis, in patients 18 years of age or older who have failed 1 or more disease-modifying antirheumatic drugs (DMARDs). KINERET can be used alone or in combination with DMARDs other than tumor necrosis factor (TNF)-blocking agents

Cryopyrin-Associated Periodic Syndromes (CAPS). Treatment of Neonatal-Onset Multisystem Inflammatory Disease (NOMID)

Deficiency of Interleukin-1 Receptor Antagonist (DIRA). Treatment of Deficiency of Interleukin-1 Receptor Antagonist (DIRA)

CONTRAINDICATION

KINERET is contraindicated in patients with known hypersensitivity to E. coli–derived proteins, KINERET, or to any components of the product.

IMPORTANT SAFETY INFORMATION

Serious Infections. KINERET has been associated with an increased incidence of serious infections in clinical trials in RA. In RA, discontinue use if serious infection develops. In NOMID or DIRA patients, the risk of disease flare when discontinuing KINERET treatment should be weighed against the potential risk of continued treatment. Do not initiate KINERET in patients with active infections.

IL-1 blocking drugs such as KINERET may increase the risk of tuberculosis (TB) or other opportunistic infections.

Use in combination with tumor necrosis factor (TNF)-blocking agents is not recommended due to potential for increased rate of serious infections.

Hypersensitivity reactions, including anaphylactic reactions and angioedema, and serious cutaneous reactions including drug reaction with eosinophilia and systemic symptoms (DRESS) have been reported. Patients with DIRA may have an increased risk of allergic reactions.

For severe hypersensitivity or allergic reactions, promptly discontinue KINERET and treat appropriately.

Immunosuppression. The impact of treatment with KINERET on active and/or chronic infections and the development of malignancies is not known.

Amyloidosis. There have been post-marketing reports of injection site amyloid deposits, and in some cases systemic AIL1RAP (IL-1 receptor antagonist protein) amyloidosis. Recommend patients to rotate their injection sites. Monitor proteinuria for systemic amyloidosis in patients with confirmed injection site amyloid deposits.

Immunizations. Live vaccines should not be given concurrently with KINERET.

Decreases in neutrophil counts may occur with KINERET treatment. Assess neutrophil counts prior to initiating KINERET treatment, and while receiving KINERET, monthly for 3 months, and thereafter quarterly for a period up to 1 year.

Serious Adverse Reactions

RA: The most serious adverse reactions were serious infections and neutropenia, particularly when used in combination with TNF-blocking agents.

NOMID and DIRA: The most serious adverse events were infections.

Most Common Adverse Reactions

RA: The most common adverse reactions (≥5%) are injection site reaction, worsening of rheumatoid arthritis, upper respiratory tract infection, headache, nausea, diarrhea, sinusitis, arthralgia, flu-like symptoms, and abdominal pain.

NOMID: The most common AEs during the first 6 months of treatment (>10%) are injection site reaction, headache, vomiting, arthralgia, pyrexia, and nasopharyngitis.

DIRA: The most common AEs are upper respiratory tract infections, rash, pyrexia, influenza-like illness, and gastroenteritis.

Post-marketing Experience

Hepato-biliary disorders (elevations of transaminases; non-infectious hepatitis), thrombocytopenia, including severe thrombocytopenia, and DRESS have been identified during postapproval use of KINERET. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

These are not all the possible risks associated with KINERET. Please see Full Prescribing Information for KINERET at https://www.kineretrx.com/hcp/

To report suspected adverse reactions, contact Sobi North America at 1-866-773-5274 or FDA at 1-800-FDA-1088.

Click here for full Prescribing Information for KINERET.

For statutory pricing disclosures, visit https://www.sobi.com/usa/en/state-disclosure-requirements.

Reference: 1. KINERET (anakinra) prescribing information. Stockholm, Sweden: Sobi, Inc. 2025.