How KINERET works

KINERET is the recombinant form of interleukin-1 receptor antagonist (IL-1Ra), which treats autoinflammation by1:

  • Supplementing naturally occurring endogenous IL-1Ra
  • Competitively binding to the IL-1 type 1 receptor (IL-1R1)
  • Blocking the activity of IL-1 cytokines that trigger the IL-1 inflammatory cascade

The effects of IL-1

Elevated levels of IL-1 may be responsible for symptoms such as:

  • Cartilage degradation2
  • Bone resorption2,3
  • Other autoinflammatory symptoms4-7
A diagram of how the KINERET® (anakinra) molecule blocks the IL-1 receptor to prevent IL-1 signaling

IL-1RAcP, interleukin-1 receptor accessory protein.

Two overlapping squares that are transparent

View the mechanism of action video to see how KINERET works

Learn about KINERET for
RA patients.

For RA patients

Learn about KINERET for
NOMID patients.

For NOMID patients

Learn about KINERET for
DIRA patients.

For DIRA patients